Day: January 4, 2017

Lactobacillus Reuteri NCIMB 30242 Reduces Bad Cholesterol by 11.64%

probiotic lowers cholesterolRaised LDL-C (low-density lipoprotein-cholesterol or bad cholesterol) levels constitute one of the major factors predisposing to cardiac disease. LDL-C reflects the mass of cholesterol contained within the LDL molecule.

Besides their vast gut-related health benefits, probiotics containing L. reuteri NCIMB 30242 target cardiovascular disease owing to their distinctive quality of lowering the LDL-C levels.


How does L. reuteri reduce LDL-C levels?

L reuteri NCIMB 30242 classically demonstrates bile salt hydrolase (BSH) activity, an enzyme that accelerates deconjugation (cleaves the covalent bonding) of bile acids. [1]


What are Bile Acids and what is Conjugation/Deconjugation of Bile Acids?

Bile acids are the products of cholesterol breakdown (catabolism) and are produced in the liver. Bile acids then conjugate (form a bond) with two amino acids, namely glycine and taurine, and are transported to the intestine. These conjugated bile acids are water-soluble and enhance the absorption of cholesterol into the bloodstream.


 L. reuteri Prompts Deconjugation

On the contrary, since the BSH activity of the lactobacillus cleaves the bond of bile acids with amino acids (prompts deconjugation), it renders cholesterol less soluble and less absorbable. Additionally, the water-insoluble, deconjugated bile acids are not excreted in the urine but in feces. In an attempt to compensate for the lost deconjugated bile acids, cholesterol is used up to produce more bile acids. This eventually represents another pathway for cholesterol reduction. [2]

Moreover, the lactobacillus species entrap cholesterol in the intestine, impeding its outflow into the blood, which is instead flushed out via feces. [1] (more…)

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