Delayed Release Capsule Technology

delayed release capsules for probioticsIntroduction

With more and more recognition of the importance of digestive health, the demand for probiotic (live bacteria) delivery systems has been on an upswing. These delivery systems differ widely in terms of efficiency to benefit an individual. A 2014 study revealed that 65% of respondents are aware of the significance of probiotics for digestive health. [1] The greatest global sale of probiotic is in the USA with the figure reported to be about $140 million in 2011 alone. [2]

The Flip Side

Nonetheless, a great percentage of probiotic bacteria cannot tolerate the stomach acid and are destroyed before making their way into the intestine and exerting their effects. Moreover, even prior to being consumed, the probiotic bacteria can get activated from fluctuations in temperature, oxygen, and humidity. This results in an unfavorable outcome with reduced concentrations of probiotics being delivered to where they are needed.

Solution Adopted by Probiotic Companies

Hence, these challenges have led probiotic companies to turn to dosage delivery systems that can ensure the preservation of their moisture and acid-sensitive ingredients. The probiotic companies are now using polymers and pills that are resistant to the low pH of the stomach and only dissolve in the alkaline pH of the intestine.

Coated Supplements

Enteric coatings are often applied to the pill-form of supplements to prevent their disintegration in the stomach environment. The coating imparts the supplement with a protective layer that cannot be eroded by the stomach acid. That being said, the manufacturing process of conventional film coatings is expensive, complex, and may also cause wastage and more yield loss. In addition to the company’s yield loss, coating techniques also fail to match the many consumers’ hunt for healthy and natural products. Moreover, coating supplements have unstable moisture content and an erratic bulk density. The multi-step manufacturing and production can be highly taxing.

Introducing Microbiome Plus+ DRcaps Capsules

At Microbiome Plus+ we use the most advanced delivery technology for our capsules to ensure you get the most out of our probiotics. Our delayed-release capsule technology uses an innovative hydroxypropyl methylcellulose (HPMC) polymer, which delivers probiotics under the simulated stomach and intestinal milieus. The HPMC is a plant-based polymer that imparts a high tensile strength to our probiotic capsule, guaranteeing an intact bacterial viability for absorption in the intestine. [3] With adequate HPMC content, we make sure that you can reap the entire benefits of the probiotic.

What makes Microbiome’s DRcaps Capsules Superior to other Probiotic Delivery Systems?

  • Our revolutionary delivery system, devised within the capsule itself provides distinctive polymer properties that delay the capsule disintegration after swallowing, facilitating it to exert maximal effects once in the intestine.
  • With low-moisture content, our DRcaps capsules help protect the nutritional contents of the dietary supplement against the harsh stomach environment in a more efficient way. This enables the probiotic supplement to pass safely through the stomach ensuring delivery of intact bacteria to your system.
  • By slowing down the capsule opening and the subsequent early release of the ingredients within, our DR system masks the taste and odor of ingredients and limits the risk of reflux from the supplement.
  • They are cost-effective in a consumer-favorable dosage form.
  • They are manufactured without the intricate process of adding acid-resistant ingredients, which, otherwise carry the risk of increasing the manufacturing time and cost.

Our vegetarian delayed-release capsule technology is an excellent alternative to the manufacturers that offer variable shelf life for the probiotic’s ingredients without an adequate proof of delivery to the intestine, while also incurring more time and cost during the manufacturing process.


  1. Chin-Lee B, Curry WJ, Fetterman J, Graybill MA, Karpa K. Patient experience and use of probiotics in community-based health care settings. Patient preference and adherence. 2014;8:1513-1520. doi:10.2147/PPA.S72276.
  2. [homepage on the Internet] US per capital spending on probiotic supplements expected to nearly double by 2016. NutraIngredients-USA; 2012. [Accessed September 23, 2014]. [updated February 2, 2012]. Available at:
  3. Govender M, Choonara YE, Kumar P, du Toit LC, van Vuuren S, Pillay V. A Review of the Advancements in Probiotic Delivery: Conventional vs. Non-conventional Formulations for Intestinal Flora Supplementation. AAPS PharmSciTech. 2014;15(1):29-43. doi:10.1208/s12249-013-0027-1.

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