How L. reuteri NCIMB 30242 Increases Vitamin D Levels

probiotics increase vitamin DVitamin D deficiency affects over 1 billion people (including children and adults) worldwide. Vitamin D is essential for bone strength. This fat-soluble vitamin functions to enhance the absorption of calcium into the bloodstream. Calcium is a key nutrient for our body, bones, and teeth. In individuals with low vitamin D levels, the bones become brittle and are prone to rickets (in children), and osteomalacia and osteoporosis (in adults). Not only are the bones weakened by the lack of vitamin D, but the gastrointestinal, cardiovascular and endocrine (causing type 2 diabetes) systems are compromised as well. Other than increasing vitamin D intake in the diet and exposing the skin to sunlight, a probiotic supplement containing L. reuteri NCIMB 30242 is proven effective at boosting the vitamin D blood levels.

 

How L. reuteri NCIMB 30242 increases vitamin D levels?

  1. L. reuteri NCIMB 30242 raises 7-dehydrocholesterol (7-DHC)
  2. L. reuteri NCIMB 30242 owns a unique bile salt hydrolase (BSH) activity. While the enzyme BSH reduces the cholesterol levels, the levels of an animal sterol called 7-DHC are also elevated in response to BSH activity. 7-DHC (present in the skin and other tissues) is a precursor to vitamin D and is converted to vitamin D on exposure to sunlight. [1]

 

Lactobacilli lower the intestinal pH

Vitamin D requires an acidic medium to be absorbed. The acid in the lactic acid bacteria reduces the pH of the intestine, which enhances the absorption of the vitamin D ingested in the diet. [1]

 

L. reuteri NCIMB 30242 enhances the expression of Vitamin D Receptor

Also recognized, is the role of L. reuteri NCIMB 30242 in augmenting the expression and activity of the vitamin D receptor (VDR). VDR facilitates the body to respond to vitamin D appropriately, increasing its uptake by the intestinal cells. [1] The VDR is also critical to maintaining a state of balance in the gut, warding off the bad bacteria, blocking inflammation, and preserving the integrity of the intestinal lining. [2] A dysfunctional VDR and consequently a paucity of vitamin D may thus provoke intestinal damage and inflammatory bowel disease.

Decreased intake of vitamin D is associated with an altered microbiome

Lately, it has been revealed that changes in the gut microbiome might contribute to the lack of vitamin D. In such instances, introducing a probiotic, primarily L. reuteri NCIMB 30242, restores the gut harmony and raises the vitamin D levels. [3] According to a Canadian study conducted in 2013, probiotic supplementation with L. reuteri NCIMB 30242 over a 9-week period significantly raises the circulating vitamin D levels by 25%. [1] The authors concluded that either more vitamin D is being absorbed or more precursor (i.e. 7-DHC) is being made after supplementation with probiotic L. reuteri NCIMB 30242.

 

Summary

A variety of factors can incite vitamin D deficiency, including but not limited to, poor diet, inadequate exposure to sunlight, obesity, dark skin, heredity, problems with absorption, or inability to convert vitamin D to its active form. Popping the probiotic, L. reuteri NCIMB 30242 boosts the vitamin D levels, offering protection for the bones, heart, and gut.

 

Written by:

Dr. Rasheed Huma

 

References

  1. Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab. 2013;98(7):2944-51. doi: 10.1210/jc.2012-4262.
  2. Kong J, Zhang Z, Musch MW et al. Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. Am J Physiol Gastrointest Liver Physiol. 2008;294(1):G208-16.
  3. Mai V, McCrary QM, Sinha R, Glei M. Associations between dietary habits and body mass index with gut microbiota composition and fecal water genotoxicity: an observational study in African American and Caucasian American volunteers. Nutr J. 2009;8:49. doi: 10.1186/1475-2891-8-49.

 

Microbiome SenseIT BSH coming soon

Microbiome SenseIT BSH is real time polymerase chain reaction (PCR) assay to determine the BSH gene copy number in fecal samples. The test is done in CLIA approved lab and is designed to provide healthcare practitioners with more information about their patients bile metabolism status.

If interested in being one of the first to use Microbiome SenseIT BSH please email us at HCP@microbiomeplus.com.

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