Bone & Heart Support

Body Essentials For Health

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Bone & Heart Support

Body Essentials For Health

Superior support for healthy heart and bones:

  • Increased blood flow
  • Healthy bones and joints
  • Improved cardiovascular health
  • With vitamin D, essential for bone formation and maintenance

60 Capsules($0.63/Capsule)

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Bone & Heart Support (Vitamin K2 + D3 with Calcium & BioPerine) | Microbiome Plus+

Advanced vitamin K2 + D3 formula with calcium and BioperineⓇ

  • Maximizes calcium absorption and use in the body*
  • Supports strong & healthy bones and joints*
  • Promotes heart & vessel health*
  • Contributes to healthy blood flow*
  • Aids immunity & energy levels*

About this product



Calcium (As Calcium Carbonate)

210 mcg/capsule

16% DV

Calcium is a mineral your body needs to maintain good health. Calcium helps keep bones and muscles healthy and strong.*

Studies on calcium show that daily supplementation of a well-absorbed form of calcium promotes bone mass in adolescents, young adults, older men, and postmenopausal women.*

Vitamin D (Cholecalciferol)

125 mcg (5,000 IU)/capsule

625% DV

Vitamin D helps the body to absorb calcium and phosphorus, minerals that play essential roles in bone development and strength.* 

Maintaining optimal vitamin D levels throughout life helps keep your bones strong and your immune system healthy.*

Vitamin D also supports healthy teeth, muscles, and heart and blood vessel function.*

Our formula contains vitamin D3 (cholecalciferol), which is more potent and better absorbed than the D2 form.

Vitamin K2 (mk-7)(As Menaquinone-7)

100 mcg/capsule

Vitamin K2 (MK-7) provides potent bone density support, helping to move calcium to where it’s needed in the body.*

Vitamin K2 also activates proteins that play a role in heart health and blood clotting, aiding healthy blood flow.*

MK-7 or Menaquinone-7 is the superior, natural form of vitamin K2 that’s included in our supplement. MK-7 is unique because it’s absorbed well and has a long-lasting action.*

BioperineⓇ (Black Pepper Fruit Extract)

5 mg/capsule

BioperineⓇ is a patented black pepper extract standardized to a minimum of 99% pure piperine. BioperineⓇ increases the absorption of almost all supplements on average by 40 to 60%. 

Once a nutrient is combined with BioPerine®, the body can absorb more of it. This means that you get more of the same nutrients with a lower dosage. 

Plus, BioPerine® supports good digestion and a normal anti-inflammatory response. 

Other Ingredients

Cellulose (vegetable capsule)

Lactose free, Gluten free, Allergen free, Hormone Free, Sugar Free

Product Description

Smarter Calcium Supplementation Your Body Can Use 

The active ingredients in Microbiome Plus+ Bone & Heart Support all work together to keep your bones and cardiovascular system healthy and strong, along with diet and lifestyle changes.*

Microbiome Plus+ Bone & Heart Support was expert-formulated for maximum absorption, so you get more out of every single active ingredient.*

Feel the difference of smarter calcium supplementation: you get bioavailable calcium, but our supplement also primes your body to get better at absorbing calcium from food.*

Most people don’t lack calcium in their diet but have difficulty absorbing it due to nutrient deficiency or gut issues. High-dose regular calcium supplements do nothing to address this issue. 

With the help of BioPerine®, our blend also maximizes your body's ability to absorb vitamins K2, D3, and calcium. It’s formulated to direct calcium to your bones. This synergistic action helps create bone mass while preventing calcium from building up in your blood vessels and causing calcification and heart disease.*

Microbiome Plus+ Bone & Heart Support is a high potency of vitamin D3 supplement (5000 IU or 125 mcg) that ensures you get enough vitamin D if you are at risk of deficiency.*

We also made sure to select the form of vitamin K2 that has the highest bioavailability and the most significant effect on bone health in humans: MK-7. Other forms of vitamin K (vitamin K1 and MK-4) can’t achieve these benefits without MK-7 (study).

The active ingredients in this blend also support good immunity and vitality, so you can finally feel uplifted and energized.*

When to Use/How to Use

Take one (1) capsule twice a day as a dietary supplement. For best results, take 20-30 min before a meal or as directed by your healthcare professional.


Backed by Science

Calcium is a mineral your body needs to maintain good health. It’s the main mineral in your bones and teeth. Without calcium, bones become brittle and weak.* 

Your heart and blood vessels also need calcium to stay healthy. When calcium is not used properly by the body, blood vessels become stiff and the heart weakens.*

Both vitamins D3 and K2 are also essential to the body's function and overall health.*

Vitamin D3 aids in absorbing calcium and phosphorus, which are necessary for bone formation and maintenance. Vitamin D3 is the body’s preferred form of Vitamin D to help maintain normal vitamin D levels.*

Approximately 29% of U.S. adults are vitamin D deficient (<50 nmol/L). While direct sunlight is a natural source of vitamin D, many people don’t get enough vitamin D from sunlight or from their diet.*

Be sure you get the vitamin D your body needs with Microbiome Plus+ easily absorbed Heart & Bone Support blend containing 5000 IU (125 mcg) of vitamin D per capsule. It was created for those with higher vitamin D needs and/or deficiency, as determined by a healthcare professional.*

Vitamin K2 works by guiding calcium to where it should be. Vitamin K2 (MK-7) controls mineral stores by activating osteocalcin, which helps rebuild the bone mineral matrix.*

Recent studies reveal that vitamin K2 with vitamin D3 together achieve added benefits in supporting the prevention of bone loss and demineralization.*

The addition of BioPerine®, a patented black pepper extract, helps your body maximize the absorption of all these nutrients by increasing your metabolism.*


  • Better calcium absorption

Our vitamin K2 + D3 formula was created to boost calcium absorption by supplying calcium and helping your body get better at absorbing it from other sources. Most people don’t lack calcium in their diet, but they can’t absorb it due to a lack of vitamins K2 and D3.*

  • Maximum bioavailability 

BioPerine® boosts the bioavailability of all active ingredients. This means maximum absorption, action, and effectiveness—helping you get the most benefits.*

  • Strong bones & healthy joints

Calcium, vitamin D, and vitamin K2 work in synergy to maintain strong and healthy bones, joints, teeth, and nails.*

Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis.*

Vitamins D3 and K2 aid calcium absorption and bone mineralization, contributing to healthy bones.* 

Vitamin K2 (MK-7) increases bone mineral density, promotes bone quality and strength, and supports collagen production, contributing to strong bones and healthy joints.* 

  • Healthy heart & muscles

Calcium is necessary to maintain regular muscle contraction and the heart’s ability to pump blood, supporting healthy blood flow and heart function.* 

Calcium also supports healthy levels of LDL, HDL, and total cholesterol.*

Vitamin D supports heart health, and low levels have been linked with heart disease. According to some studies, calcium supplements without vitamin D are a possible contributor to heart attacks, especially in women (study).*

By directing calcium to the bones, vitamin K2 (MK-7) may also help prevent calcium buildup in blood vessels. This may help prevent blood vessel calcification, linked with arterial plaques and heart disease (study).*

New research reveals that people with higher vitamin K2 dietary intake may have healthier hearts and stronger blood vessels (study).* 

Vitamin K2 (MK-7) also helps support a healthy anti-inflammatory response and aids tissue regeneration.*

  • Energy levels & immunity 

Vitamin D is key to good immunity and vitality. Supplementation is recommended for people who don’t get enough natural sunlight regularly.*

Vitamin D3 supplementation boosts energy and mood when sun exposure is not possible or adequate.*

Once you start supplementing, a spike in energy levels may signal that your vitamin D3 levels are getting optimal and that you are absorbing calcium properly.*

Normal vitamin K2, vitamin D, and calcium levels also support reproductive and hormonal health, helping you feel at your best.*

  • Trusted brand

Microbiome Plus+ is a science-based brand. We are dedicated to producing only high-quality potent supplement blends. Product safety and quality are our top priorities. All our supplements are supported by rigorous scientific studies and formulated by experts. 

Unlike many K2 + D3 supplements, our non-GMO formula is expertly formulated in a cGMP-registered facility in the United States. You can rest assured we manufacture our Heart & Bone Support supplement without any additives, synthetic dyes, or artificial flavors. 

This product is also gluten-free and lactose-free. 

What are the benefits of vitamin D and vitamin K2?

Vitamin D is a powerful nutrient that does everything from supporting bone, teeth, muscle, and immune health to aiding the absorption of calcium.*

Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis.*

Vitamin K comes in two main forms: Vitamin K1 (plant-derived) and Vitamin K2 (usually animal-derived). Vitamin K2 (MK-7) is a plant-based, natural form that helps maintain a healthy heart and blood vessels, and it works with calcium to support bone health.*

Why take Vitamin D and Vitamin K2 together?

Vitamin D and K2 act in synergy to support the bones, heart, brain, and immune system. Vitamin D and K2 work better for bone health when taken together than vitamin D3 alone.*

Vitamin K2 and vitamin D are the perfect pair. Vitamin D helps your body absorb calcium. Vitamin K2 helps your body absorb vitamin D and get it in the right place, and both vitamin K2 and D help guide calcium to your bones.*

Together, vitamin D and vitamin K2 also activate proteins that ensure healthy blood flow, blood clotting, and blood vessel elasticity. In optimal amounts, these two vitamins also help prevent calcium buildup in the body.* 


Who should not use this supplement? 

Do not take this supplement if you are on blood thinner medications. Vitamin K, including vitamin K2 (MK-7) interacts with blood thinners and anticoagulants like warfarin (Coumadin®). Vitamin K may reduce the activity of these drugs, and sudden changes in blood vitamin K levels in people taking these medications can have serious and unexpected side effects. 

Please consult your doctor before use if you have a health condition and/or take any medications to avoid drug-supplement interactions. 

Should I take this supplement with a meal?

It’s recommended to take one capsule twice a day up to 20-30 min before a meal or as directed by your healthcare professional. 

Taking the supplement shortly before a meal containing some fats supports the absorption of fat-soluble vitamins. 

Can I use this supplement while pregnant?

Microbiome Plus+ Heart & Bone blend is suitable for use during pregnancy. However, you should consult a physician before using this or any dietary supplement if you are pregnant or breastfeeding to make sure that there aren’t any contraindications in your case.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Keep out of reach of children. Consult a physician if you are pregnant or nursing; have or had a medical condition, or are taking prescription drugs. If you have any adverse effects to the product, stop taking the product immediately and consult your physician.