Gastrointestinal Combo Probiotic & Prebiotic Fiber

Heart Health & Bloating

Gastrointestinal Combo Probiotic & Prebiotic Fiber

Heart Health & Bloating

Symbiotic formulation with prebiotic to help boost the probiotic's qualities.

Clinically Proven to:

  • Lower LDL cholesterol by 11.64%
  • Increase vitamin D absorption by 25.5%

56 capsules (4 wk supply) ($0.85/Capsule)

Purchase Options
    • Buy 2 Save 10%
    • Buy 3 Save 12%
    • Buy 4 Save 15%

    *Valid for One-time purchase only

    *Automatic code at checkout

    • US and International shipping
    • 1 year money-back guarantee
    • Trusted by doctors


    Microbiome Plus+ Probiotic NCIMB 30242 LRC is very unique because it is considered a “heart healthy probiotic” and it is the only probiotic that has been clinically proven to significantly lower LDL cholesterol. Read Study Here

    Low serum 25-hydroxyvitamin D is a risk factor for osteoporosis, cardiovascular disease, diabetes, and cancer. Many people suffer from vitamin D deficiency, and our unique probiotic has been shown to increase vitamin D levels. Read Study Here

    With low-moisture content, our delayed release capsules help protect the nutritional content of our probiotic against the harsh stomach environment. This enables the probiotic supplement to pass safely through the stomach, ensuring delivery of intact bacteria to your system. Read More

    Many studies have demonstrated the numerous health benefits of probiotics and the gut. With a healthy microbiome, your body is better equipped to defend against harmful bacteria that spread disease and illness.

    Our probiotic strain NCIMB 30242 reduces LDL cholesterol and improves many other areas of your health. The reduction of LDL cholesterol strengthens your cardiovascular system and other important health markers. Read Study Here

    Microbiome Plus+ NCIMB 30242 has been proven in a human clinical trial to considerably improve gastrointestinal health. Subjects in the randomized, double-blind, placebo-controlled study reported significant GI health improvement. Read Study Here

    Not only is L. reuteri NCIMB 30242 one of the few probiotics given GRAS (Generally Recognized as Safe) status, our prebiotic fiber scFOS is designed to boost the effectiveness of our probiotic in a synbiotic combination that synergistically promotes gastrointestinal health.

    Microbiome Plus+ Gastrointestinal Probiotic and Prebiotic Combo is a powerful supplement supported by rigorous scientific analysis. Many clinical studies show the benefits, safety, and effectiveness of L. reuteri NCIMB 30242. Read ALL Study Here


    Our well-researched formula is recommended by doctors for a reason. It’s among the few prebiotic and probiotic supplements clinically proven to support digestive health.* 
    Our prebiotic and probiotic combo is a perfect choice because:
    • Probiotics lower LDL cholesterol
    • Probiotics promote heart health
    • Probiotics increase Vitamin D absorption
    • Probiotics boost immunity
    • Prbiotics improve overall health
    • Prebiotics boost these effects!


    Your body wants our award-winning, heart-healthy probiotic. Clinically researched for supporting vitamin D, LDL cholesterol, total cholesterol, C-reactive protein, and fibrinogen levels, our probiotic can lower cholesterol, promote heart health, and improve immune health.
    Each capsule contains 3.5 billion CFU and starts acting only once it reaches your colon.*


    Our fiber supplement is formulated to work with our probiotic to support gut health and promote the growth of beneficial gut bacteria. It’s targeted “food” for our probiotics. Each prebiotic tablet contains 600 mg of concentrated scFOS fiber.
    No surprises, just science.*


    All ingredients are sourced from renewable and sustainable sources

    Probiotic Ingredients

    Product Ingredient

    Lactobacillus reuteri NCIMB 30242

    3.5 Billion AFU/capsule

    Our primary ingredient is our unique probiotic strain which has been through rigorous clinical trials performed by independent labs and researchers and published in 7 peer-reviewed scientific papers

    Read More read more

    Other Ingredients

    In each capsule:

    • Microcrystalline cellulose
    • Silicone dioxide
    • Magnesium stearate
    • Vegetable capsule (hypromellose, titanium dioxide)

    Prebiotic Ingredients

    Product Ingredient



    Short-chain fructooligosaccharides (scFOS) are natural dietary fibers that belong to the fructans family and are proven to aid in healthy bacterial growth and prevent the colonization and growth of pathogenic gut bacteria.

    Other Ingredients

    In each capsule:

    • Microcrystalline cellulose
    • Dicalcium phosphate
    • Stearic acid
    • Magnesium stearate
    • Croscarmellose sodium
    • Silicon dioxide
    Enhance Digestive Health

    Enhance Digestive Health

    Increase Vitamin D

    Increase Vitamin D

    Prebiotics Boost Probiotic Benefits

    Prebiotics Boost Probiotic Benefits

    Boost Energy and Immunity

    Boost Energy and Immunity

    Developed by Doctors

    Developed by Doctors

    Developed by Doctors

    Lower Cholesterol

    allergy safe
    allergy safe
    allergy safe
    allergy safe

    Microbiome Plus+ Pre and Probiotic Supplements Compared to Other Probiotics

    Microbiome Plus+ pre and probiotics

    Brand A

    Brand B

    Clinically researched pre and probiotic combination

    GRAS status

    CFU count per strain per capsule




    Prebiotic fiber dosage per capsule/tablet

    600 mg

    200 mg


    Acid-resistant capsule

    Designed for survivability

    Dairy free, gluten free, and soy free

    Shelf-stable bottle

    Supports already healthy vitamin D levels

    Supports already normal cholesterol

    Encourages gut microbiome diversity

    Histamine-release free

    IBS safe

    Prebiotic-Probiotic Combo Capsules Box | Microbiome Plus+

    Take one probiotic capsule and one prebiotic tablet twice daily with meals or as directed by a physician.

    Take one probiotic capsule and one prebiotic tablet twice daily with meals or as directed by a physician.

    Probiotics for Cholesterol, Recommended By Doctors

    — Dr. Deanna M. Cherrone, Natural Health and Healing Clinic
    "I have been using MicroBiome Plus for several years. It has greatly benefitted my patients with gut problems and those with cardio metabolic issues as well.

    — Dr. Deanna M. Cherrone, Natural Health and Healing Clinic

    Know what you’re Getting

    RIGOROUSLY SELECTED ACTIVE INGREDIENTS: Whereas many companies use clinically untested blends of many probiotics and prebiotics just to achieve a high CFU count, we stick to what we know. We selected only two active ingredients that work both individually and together.
    THE POWER OF SYNBIOTICS: Our science-based and clinically proven synbiotic formula relies on synergy and supports your overall health and well-being. Synbiotics are supplements that combine the power of probiotics and prebiotics, increasing each other’s benefits in the form of synergism.

    About L. Reuteri NCIMB 30242 Probiotic (LRC)

    The probiotic in Microbiome Plus+ Gastrointestinal has been shown in clinical trials to help support normal inflammatory response in addition to supporting digestive health.*

    • L. reuteri NCIMB 30242 is the only probiotic shown to help maintain healthy bile metabolism*
    • By promoting healthy bile metabolism L. reuteri NCIMB 30242 has multiple health benefits*
    • L. reuteri NCIMB 30242 promotes digestive health and maintains a healthy digestive system*
    • Helps maintain healthy levels of cholesterol – (Lowers LDL Cholesterol)*
    • Helps maintain healthy levels of vitamin D*
    • Supports normal inflammatory response*
    About L. Reuteri NCIMB 30242 Probiotic (LRC)

    Microbiome Plus+ Pre and Probiotics Benefits

    NORMAL CHOLESTEROL & HEART HEALTH: Normal cholesterol levels are important for your cardiovascular system. Our Microbiome Plus+ Lactobacillus Reuteri NCIMB 30242 probiotic provides clinically tested natural support for your already normal total and LDL cholesterol levels. It also helps sustain healthy levels of already normal C-reactive protein, apolipoprotein B-100, fibrinogen, and plant sterols. Normal levels of these factors support your heart, blood vessels, and blood clotting. 

    VITAMIN D: Our combo contains the only clinically researched probiotic strain that supports keeping already normal vitamin D blood levels in check. Normal vitamin D levels help build and maintain strong bones, absorb calcium in the gut, and balance immune health.

    IMMUNE SYSTEM SUPPORT: 80% of your immune system in your gut. By encouraging a healthy gut microbiome and already normal vitamin D levels, our probiotics and prebiotics contribute to optimal immune system function in healthy people.

    WEIGHT CONTROL, BILE & COLON HEALTH: Our pre and probiotics help maintain a healthy gut lining, normal fat digestion, and optimal metabolism by freeing up bile acids. Normal levels of free bile acids may help strengthen the intestinal lining. A diverse microbiome supports the body in maintaining insulin sensitivity and healthy weight, along with diet and exercise.

    DIGESTION, STOMACH & BLOATING RELIEF: Microbiome Plus+ probiotics and prebiotics assist good digestion, gastrointestinal health, and gut microbiome diversity. Gut microbiome dysbiosis has been linked with stomach discomfort, pain, and bloating.

    BOWEL MOVEMENT SUPPORT: Our pre and probiotics work with your gut to encourage healthy bowel movements, optimal bowel function, and passage of stools. By helping maintain a strong intestinal lining, Microbiome Plus+ Lactobacillus Reuteri NCIMB 30242 supports the body in preventing harmful organisms from crossing from the gut into the bloodstream. Prebiotics enhance its benefits.

    IBS RELIEF: Our combo is IBS safe. Lactobacillus Reuteri NCIMB 30242 supports normal bile acid levels, which encourages a balanced gut ratio of Firmicutes to Bacteroidetes in healthy people. People with IBD often have an imbalanced Firmicutes to Bacteroidetes ratio, according to studies. Plus, we chose scFOS fiber because it was clinically researched for supporting microbiome health in people with IBS.
    Microbiome Plus+ prebiotics and probiotics are manufactured in GMP-certified US facilities, rooted in science, and backed by many clinical trials (Read the studies here: Jones et al., 2011, Jones & Prakash, 2012; Jones et al., 2013, Jones et al., 2013; Martoni et al., 2015; Jones et al., 2011; Jones et al, 2012). 

    Prebiotics & Probiotics for Women and Men

    Microbiome Plus+  Gastrointestinal Combo supports both men’s and women’s health with just two select active ingredients: probiotic L. Reuteri NCIMB 30242 and prebiotic scFOS fiber.

    PRE AND PROBIOTICS FOR WOMEN: Our prebiotics and probiotics support women’s digestive and overall health. Lactobacillus Reuteri probiotics are a normal part of a healthy vaginal, breast milk, and gut flora in women. Prebiotic fiber also supports weight control, a sense of fullness, and regular bowel movements. Plus, a healthy microbiome helps the body maintain a healthy vaginal pH balance.

    PRE AND PROBIOTICS FOR MEN: Our pre and probiotic combo supports men’s health by contributing to normal gastrointestinal, metabolic function, sugar control, and overall health. Lactobacillus reuteri probiotics support male fertility and testosterone levels already in the normal range in healthy men. Fiber supports normal bowel movements, aids in achieving a healthy weight, and contributes to prostate health.

    Prebiotic Fiber scFOS

    Prebiotic Fiber scFOS

    • Fuels the growth of beneficial gut bacteria, inhibits the growth and colonization of harmful bacteria, and maintains a balance of healthy intestinal flora*
    • Supercharges your digestive and immune systems*
    • Normalizes bowel irregularities
    • Enhances the production of an enzyme called bile salt hydrolase by promoting a healthy gut microbiome, which facilitates healthy bile metabolism*
    • Improves the absorption of micronutrients and is helpful for individuals who are unable to acquire specific nutrients from their diet*
    • Reduces gastrointestinal inflammation with its synbiotic combination with L. reuteri NCIMB 30242 probiotic*
    Doctor with Clipboard | Microbiome Plus+

    Backed By Science

    • Supports gut health, good digestion
    • Supports healthy LDL cholesterol already within the normal range
    • Keeps already normal vitamin D levels in check
    • Supports cardiovascular health by encouraging already normal levels of CRP, fibrinogen, plant sterols, and apolipoprotein B-100
    • Supports microbiome diversity in IBS
    • Safe and well-tolerated
    • Well-researched prebiotic fiber for adults

    What is Microbiome Plus?

    More Information


    PROBIOTIC Capsule: Lactobacillus reuteri NCIMB 30242 3.5 billion CFU. Other Ingredients: microcrystalline cellulose, silicon dioxide, magnesium stearate, vegetable capsule (hypromellose, titanium dioxide). PREBIOTIC scFOS Tablet: scFOS (Short-chain fructo oligosaccharides) 600mg. Other Ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, magnesium stearate, croscarmellose sodium and silicon dioxide.

    About Microbiome Plus+ Gastrointestinal - Probiotic & Prebiotic Combo

    Microbiome Plus+ Gastrointestinal Probiotic and Prebiotic Combo is a powerful supplement supported by rigorous scientific analysis. L. reuteri NCIMB 30242 is one of the few probiotics given GRAS (Generally Recognized as Safe) status, our prebiotic fiber scFOS is designed to boost the effectiveness of our probiotic in a synbiotic combination that synergistically promotes gastrointestinal health.


    • Do Microbiome Plus+ probiotics need to be refrigerated?
      No. Our probiotics are shelf stable and don’t need to be kept in the fridge.
    Buy Now microbiome-plus-gastrointestinal