Probiotic 40 Billion Blend with Prebiotics

Superior Gut Health

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Probiotic 40 Billion Blend with Prebiotics

Superior Gut Health

  • Advanced strength probiotic blend with 40 billion CFUs per serving*.
  • 4 probiotic strains and 2 prebiotics backed by research*
  • Powerful aid for restoring good gut bacteria and digestive health*
  • Supports a strong immune system, stress reduction, and overall wellness*
  • Maktrek® Bi-Pass Technology ensures all probiotics reach your gut alive *
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About Microbiome Plus+ 40 Billion CFU Probiotic with Prebiotics



Proprietary Blend of Probiotic Bacteria MAKTREK® (Bi-Pass Technology)

40 billion CFUs/2 capsules

Ensures live bacteria reach your gut.*

Most probiotics on the market break down before they enter the gut.*

MAKTREK® technology uses a protective coating on capsules to make probiotics shelf-stable and resistant to stomach and bile acids. This ensures that every single probiotic stays alive on your shelf and reaches your intestines, providing you with maximum benefits.*

Lactobacillus Acidophilus (La-14)

Helps boost gut and vaginal flora health, digestion, and immunity.*

  1. Acidophilus (Lactobacillus Acidophilus) is a naturally-occurring bacteria in the gut, mouth, and vagina.*

  1. Acidophilus (Lactobacillus Acidophilus) has been incredibly well-researched for helping with diarrhea, immunity, nutrient absorption, and fighting off infections. That’s why this probiotic is found in many quality probiotic blends, including ours.*

La-14, found in this blend, may also be beneficial for vaginal health and overall women’s health. Overall, this strain has been through 50 scientific studies, including 18 clinical trials.*

Bifidobacterium Lactis (Bl-04)

Supports good digestion, immunity, and respiratory health.*

  1. lactis (Bifidobacterium lactis) is another all-around probiotic bacteria that normally live in the gut.*
  2. lactis has been through research for helping with antibiotic-associated diarrhea, constipation, and the absorption of various vitamins and minerals. This probiotic is also good for respiratory and anti-allergy support.*

Bl-04, the B. lactis strain in our blend, has been through more than 20 clinical trials.*

Lactobacillus Plantarum (Lp-115)

Great for gut health, nourishment, and immune balance.*

Lactobacillus Plantarum (L. plantarum) normally lives in the gut, but it’s also found in many traditional fermented foods like brined olives and sauerkraut.*

Lactobacillus Plantarum Lp-115, found in our blend, has been studied for balancing the immune response. It helps the body fight off infections, contributes to an anti-inflammatory response, and provides anti-allergy support.*

Lactobacillus Paracasei (Lpc-37)

Calms the mind and helps with stress reduction.*

Lacticaseibacillus paracasei (L. paeacasei) has a long history of safe use. It’s known to support digestive and mental health.*

Lpc-37, the strain in our blend, has been through clinical studies for reducing feelings of chronic stress and anxiety and improving sleep. This strain has been cited in more than 60 scientific publications, including over 18 clinical trials.*

Marine Polysaccharide Complex

Protects live probiotics and boosts their benefits.*

The Marine Polysaccharide Complex contains a matrix of natural sugars from seaweed that act as a protective coating and prebiotic.*

Our natural seaweed extract stays wrapped around the probiotic-filled capsules until it reaches the gut. There it releases probiotics and degrades. Its active compounds then help feed “good” gut bacteria, enhancing the benefits of the probiotics in this blend.*

Plus, the released marine polysaccharides also help protect the gut lining.*


Provides prebiotic fiber and boosts digestion.*

Fructooligosaccharide (FOS) is a prebiotic fiber. It helps fuel healthy gut bacteria, support digestion, and enhance the absorption of vitamins and minerals.*

Fructooligosaccharide also helps maintain healthy blood sugar and cholesterol levels.*


Muscle mass and bone health support.*

L-leucine is an essential amino acid that helps the body make proteins.*

L-leucine has recently been through clinical trials for improving muscle mass and bone strength in the elderly, along with a probiotic and omega-3s*

Other Ingredients

Cellulose (vegetable capsule), Rice maltodextrin.

Gluten-free Lactose-free Allergen-free Hormone-free All natural Corn-free Sugar-free

Product Description

Good health starts in your gut

At Microbiome Plus+, we know that a healthy gut is key to good health and wellness.*

Your gut health and microbiome impact your digestion, immunity, mood, heart, hormones, and so much more. That’s why we’re passionate about creating science-based probiotic blends that support whole-body health through the gut.*

Unfortunately, many factors common to the modern lifestyle can disrupt the microbiome and affect digestive and immune health—be it an unhealthy diet, stress, medications (including antibiotics), or others. A quality probiotic can help establish healthy microbial balance and boost multiple areas of health.*

Our 40 Billion Probiotic Blend with Prebiotics is formulated to help you regain optimal gut health, replenish your “good” gut bacteria, and boost your overall well-being.*

Microbiome Plus+ 40 Billion Probiotic offers advanced support for occasional digestive upset. It’s suitable for people who occasionally experience diarrhea, constipation, or both.*

It’s also great for anyone looking for immune and respiratory support, including individuals suffering from seasonal allergies.*

Specific strains in our blend also provide targeted support for vaginal health and chronic stress reduction.*

Plus, we don’t know of anyone who wouldn’t benefit from a healthier and more diverse microbiome! Microbiome Plus+ 40 Billion Probiotic is a smart choice for anyone who cares about their gut health and overall wellness.*

Clinically tested strains that you can trust

Many probiotic supplements contain unknown strains—they only list the genus and species on the bottle. However, probiotic benefits are strain-specific! Only specific strains have been through clinical trials and proven to be safe and effective.*

Microbiome Plus+ 40 Billion features four clinically tested probiotic strains in one convenient acid-resistant capsule. Our formula also includes two well-researched prebiotics that boost the benefits of the probiotics.*

High-strength probiotics that your body can use

Some brands will list a high colony-forming units (CFU) count, but they won’t mention how many live probiotics will make it to the gut where the body can use them. 

Microbiome Plus+ 40 Billion contains 40 billion CFUs per serving (2 capsules). The live probiotic bacteria in each capsule are protected by MAKTREK® Bypass Technology. This unique patented technology uses a seaweed extract  (marine polysaccharide complex) to coat the probiotic capsule, making it resistant to stomach acid, bile acids, and enzymes in the stomach and intestines.*

MAKTREK® dissolves only once it reaches the lower gut, where probiotic bacteria normally live. Here it releases carefully protected live probiotics and prebiotics. The added perk is that MAKTREK® itself turns into a probiotic once it dissolves, providing added gut and immune support.*

When to Use/How to Use

Take two (2) capsules daily as a dietary supplement. For best results, take one (1) capsule during the day and one (1) capsule in the evening. Do not exceed two capsules per day.


Backed by Science

Improve your gut health and support immune function with one science-backed probiotic and prebiotic blend:

  • Contains four probiotic strains and two prebiotics that altogether have been cited in hundreds of scientific publications and tested in dozens of clinical trials*
  • A shelf-stable, high-strength blend containing 40 billion probiotic CFUs*
  • MAKTREK® (Bi-Pass Technology) ensures live bacteria make it to the lower gastrointestinal tract, maximizing the benefits*
  • Formulated to boost the absorption of nutrients, replenish healthy gut bacteria, and enhance overall wellness*


Healthy gut bacteria

Microbiome Plus+ 40 Billion contains probiotic bacteria and prebiotics that support balanced gut flora and digestive function. It’s a great choice for anyone looking to replenish their gut microbiome and enhance digestion.*

By contributing to gut health and balancing the gut microbiome, probiotics can positively affect many other areas of health.*

Immune and respiratory health

Probiotics and prebiotics in this blend help support healthy immune function and respiratory health.*

All probiotics and prebiotics in the blend are considered to be immune-supportive, while Bifidobacterium Lactis (Bl-04) and Lactobacillus Plantarum (Lp-115) are good for anti-allergy support, meanwhile, Bl-04 is also a respiratory aid.*

Stress reduction

Microbiome Plus+ 40 Billion offers anti-stress action.*

Lacticaseibacillus paracasei (Lpc-37) may help reduce feelings of chronic stress and anxiety and help you get a good night’s sleep.*

Women’s health 

Lactobacillus Acidophilus (La-14) contributes to immune resilience and vaginal flora balance in women. La-14 may help support healthy vaginal colonization through oral supplementation.*

Protected live bacteria

All probiotic supplements should contain live bacteria, but many don’t. Microbiome Plus+ 40 Billion delivers probiotics in an acid-resistant and moisture-resistant capsule.*

Our patented technology protects the live bacteria while they pass through the harsh environment of your stomach, helping all probiotics make it to your lower GI tract where they belong.*


What is a high CFU in probiotics? Is a 40 billion CFU probiotic too much?

Many probiotic supplements contain 1 to 10 billion CFU per dose, but some products contain up to 50 billion CFU or more.*

Some studies show that 10-20 million CFU are adequate for probiotic benefits for certain strains. However, larger CFUs and/or specific strains may be more suitable for certain individuals. 

The number of CFU a person needs depends on their health goals and is differs based on the probiotic strains used. For example, a probiotic supplement may contain a high CFU count but unidentified strains that have not been clinically tested. This makes it worthless to most people who are looking for a quality, science-backed product.*

On the other hand, a high CFU count does not mean that many live probiotic bacteria will survive sitting on the shelf or passing through the stomach. If the probiotic supplement wasn’t formulated to have shelf-stability and acid resistance, most live bacteria will get lost before they even make it to your gut.*

Microbiome Plus+ 40 Billion contains 40 billion CFUs per serving (2 capsules) consisting of four probiotic strains and two prebiotics that have been well-researched and tested in dozens of clinical trials. MAKTREK® (Bi-Pass Technology) ensures live bacteria make it to the lower gastrointestinal tract unaffected by stomach acid and gut enzymes.*

Who should not take this supplement?

Microbiome Plus+ 40 Billion is a good choice for most people who want to support their gut health and overall wellness. 

However, it might not be suitable for everyone. 

Please consult your doctor before use if you have a severely compromised immune system or any other health condition and/or take any medications. It’s also recommended to consult your doctor before use if you are pregnant or breastfeeding. 

Keep out of reach of children. Do not use if the safety seal is damaged or missing. Store in a cool, dry place.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Keep out of reach of children. Consult a physician if you are pregnant or nursing; have or had a medical condition, or are taking prescription drugs. If you have any adverse effects to the product, stop taking the product immediately and consult your physician.